Linda C. Samuelson is Professor of Molecular & Integrative Physiology at the University of Michigan. Following graduate studies at the University of Chicago and postdoctoral training at the University of Michigan, Dr. Samuelson joined the Physiology Department at the University of Michigan as an Assistant Professor in 1991. Subsequently she received a joint appointment in the Department of Internal Medicine in the Division of Gastroenterology. In 2011, she was appointed as the John A. Williams Collegiate Professor of Gastrointestinal Physiology, and currently serves as the Associate Director of the Center for Organogenesis in the University of Michigan Medical School.
Dr. Samuelson’s research examines the development and function of gastrointestinal tissues, probing the mechanisms regulating epithelial cell proliferation and differentiation in health and disease. Recent studies have focused on the importance of the Notch signaling pathway to regulate stem and progenitor cells in the intestine and stomach. This work has defined key transcriptional effectors regulating cell fate and demonstrated a distinct function for Notch signaling to maintain gastrointestinal stem cells. Her laboratory also investigates how signaling pathways that play a fundamental role for epithelial cell renewal in the gastrointestinal tract might be disturbed to promote excessive growth that may lead to cancer.
Dr. Samuelson’s expertise and stature in the field have been recognized by service on National Institutes of Health review panels, and she has served as associate editor for Physiological Genomics, Annual Review of Physiology and Gastroenterology. An exceptional mentor and teacher of students at all levels — including undergraduate, graduate and postdoctoral — her contributions to graduate education include serving as Department of Physiology graduate program chair.